Cardiorenal syndrome: acute kidney injury secondary to cardiovascular disease and role of protein-bound uraemic toxins
نویسندگان
چکیده
منابع مشابه
Cardiorenal syndrome: the emerging role of protein-bound uremic toxins.
Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists. Despite advances in treatment of both cardiovascular and kidney disease, cardiorenal syndrome remains a major global health problem. Characteristic of the pathophysiology of cardiorenal syndrome is bidirectional cross-talk; mediators/substances activated by the dise...
متن کاملUraemic toxins and cardiovascular disease.
When renal failure develops, uraemic retention solutes are retained which are normally excreted by the healthy kidneys. If these retention solutes exert biochemicalu biological activity, they are called uraemic toxins. According to their physico-chemical characteristics, they can be subdivided into [1]: (i) small water-soluble compounds (-500 Da, prototype urea); (ii) the larger so-called middl...
متن کاملProtein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients
Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem. Moreover, the occurrence rates of cardiovascular events among CKD patients increase even in cases in which patients undergo hemodialysis, and t...
متن کاملVasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins.
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), while CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney but also the vascular system through a vast array of contributing factors. In a...
متن کاملProtein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome.
Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart. It has been suggested that PBUTs are likely to be a potential missing link in cardiorenal syndrome, based on the high incidence of cardiovascular ev...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2014
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2014.273078